Target intelligence / Profile preview

14-alpha-lanosterol demethylase

Molecular classification: Enzyme, Cytochrome P450, Monooxygenase

Overview

Lanosterol 14α-demethylase catalyzes an essential checkpoint reaction in sterols' transformation within eukaryotic cells—removing the C‑methyl group at position‑14 of lanosterol—and serves as both a fundamental metabolic enzyme and an important pharmacological target.

Other names: Lanosterol 14α-demethylaseCytochrome P450 51P45014DM

Mechanism of action

Inhibition of ergosterol synthesis by binding to the heme iron within the active site.

Biological functions

Sterol biosynthesisCholesterol biosynthesisErgosterol biosynthesisDemethylation

Disease associations

Infection

Safety considerations

Drug resistance (mutations altering drug binding or increased efflux)

Interacting drugs

Fluconazole

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