Molecular Classification
Enzyme, Cytochrome P450, Monooxygenase
Other Names
Lanosterol 14α-demethylase, Cytochrome P450 51, P45014DM
Disease Roles
Infection

14-alpha-lanosterol demethylase Overview

Lanosterol 14α-demethylase catalyzes an essential checkpoint reaction in sterols' transformation within eukaryotic cells—removing the C‑methyl group at position‑14 of lanosterol—and serves as both a fundamental metabolic enzyme and an important pharmacological target.

Mechanism of Action

Inhibition of ergosterol synthesis by binding to the heme iron within the active site.

Biological Functions

Sterol biosynthesis
Cholesterol biosynthesis
Ergosterol biosynthesis
Demethylation

Disease Associations

Infection

Safety Considerations

  • Drug resistance (mutations altering drug binding or increased efflux)

Interacting Drugs

Fluconazole
Azole antifungals