Target intelligence / Profile preview

15-hydroxyprostaglandin dehydrogenase (15-PGDH)

Target: 15-PGDH
Molecular classification: Enzyme, Short-chain alcohol dehydrogenases/reductases

Overview

15-hydroxyprostaglandin dehydrogenase (15-PGDH), encoded by the HPGD gene, is a key enzyme responsible for the metabolic inactivation of prostaglandins. It catalyzes the NAD+-dependent oxidation of the 15-hydroxyl group of prostaglandins to yield inactive 15-keto metabolites. Loss or downregulation of HPGD expression has been observed in several cancers, leading to increased levels of pro-tumorigenic prostaglandins. It acts as an anti-inflammatory mediator and a tumor suppressor.

Other names: HPGD

Mechanism of action

Catalyzes the NAD+-dependent oxidation of the 15-hydroxyl group of prostaglandins, inactivating them.

Biological functions

Prostaglandin catabolismRegulation of inflammationRegulation of cell proliferationHomeostasis

Disease associations

CancerInflammation

Interacting drugs

Histone deacetylase inhibitors

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