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Target intelligence / Profile preview
17β-Hydroxysteroid Dehydrogenase (HSD17B)
- Target
- HSD17B
- Molecular classification
- Enzyme, Oxidoreductase, Short-chain dehydrogenase/reductase (SDR) superfamily, Aldo-keto reductase (AKR) (for type 5)
01
Overview
17β-Hydroxysteroid dehydrogenases (17β-HSDs) are a family of enzymes that catalyze the interconversion between less active and more active forms of estrogens and androgens. They play a crucial role in regulating local and systemic steroid hormone levels, influencing endocrine function and hormone-dependent diseases. Different isozymes exhibit varying substrate specificities and tissue distributions, allowing for fine-tuned control of hormone action. Inhibitors or modulators targeting specific HSD isoforms are under investigation for therapeutic use against hormone-dependent diseases.
- Other names
- 17-ketosteroid reductase17-KSR
02
Mechanism of action
Inhibition or modulation of specific HSD17B isoforms to alter local and systemic steroid hormone levels.
03
Biological functions
Steroid hormone metabolismRegulation of estrogen levelsRegulation of androgen levelsIntracrine regulation of hormone actionSteroidogenesis
04
Disease associations
Hormone-dependent cancers (e.g., breast cancer, prostate cancer)Reproductive disordersEndocrine disorders
05
Safety considerations
Potential disruption of normal hormone balanceOff-target effects due to isoform cross-reactivityDevelopment of resistance to inhibitors
06
Interacting drugs
HSD17B inhibitors
1 more in the full profile.
07
Biomarkers
Expression levels of specific HSD17B isoforms in tissuesEstradiol levelsTestosterone levelsEstrone levelsAndrostenedione levels
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