Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
17β-Hydroxysteroid Dehydrogenase Type 13 (HSD17B13)
- Target
- HSD17B13
- Molecular classification
- Enzyme, Short-chain dehydrogenase/reductase (SDR) family, Oxidoreductase
01
Overview
17β-Hydroxysteroid dehydrogenase type 13 (HSD17B13) is an enzyme primarily expressed in the liver and associated with lipid droplets. It belongs to the short-chain dehydrogenase/reductase (SDR) family and catalyzes oxidation-reduction reactions involving lipid substrates like retinol. While initially thought to be involved in steroid metabolism, it primarily contributes to hepatic fatty acid metabolism. HSD17B13 is upregulated in NAFLD, and loss-of-function mutations are protective against cirrhosis and HCC. It interacts with ATGL, influencing lipolysis and lipid accumulation. Therapeutic strategies focus on inhibition or modulation of its activity to treat NAFLD/NASH.
- Other names
- NIIL497SCDR9SDR16C3
02
Mechanism of action
Inhibition of HSD17B13 activity, modulation of Ser33 phosphorylation
03
Biological functions
Oxidation/reduction of retinol/lipid substratesHepatic fatty acid metabolismLipid droplet regulationLipogenesisLipolysis
04
Disease associations
Non-alcoholic fatty liver disease (NAFLD)CirrhosisHepatocellular carcinoma (HCC)
05
Safety considerations
Overexpression can promote lipogenesis and fibrosisPrecise function of HSD17B13 remains largely unknown, requiring careful consideration during therapeutic targeting
06
Interacting drugs
BI‑3231
1 more in the full profile.
07
Biomarkers
HSD17B13 expression levelsrs72613567:TA genotype
Beyond the preview
Go deeper on 17β-Hydroxysteroid Dehydrogenase Type 13 (HSD17B13).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on 17β-Hydroxysteroid Dehydrogenase Type 13 (HSD17B13).