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Target intelligence / Profile preview
Aldo-keto reductase family 1 member C3 (AKR1C3)
- Target
- AKR1C3
- Molecular classification
- Enzyme, Oxidoreductase, Aldo/keto reductase superfamily
01
Overview
Aldo-keto reductase family 1 member C3 (AKR1C3) is a cytosolic enzyme involved in the metabolism of steroids and prostaglandins. It plays a significant role in hormone-dependent cancers, particularly prostate, hepatocellular, and esophageal cancers, where it can contribute to tumor growth and resistance to therapy. AKR1C3 functions primarily as a reductase, converting aldehydes and ketones to alcohols, and has both catalytic and non-catalytic roles. It is considered a therapeutic target for inhibiting tumor growth and overcoming resistance.
- Other names
- 17β-hydroxysteroid dehydrogenase type 517β-HSD5HSD17B53α-hydroxysteroid dehydrogenase type 23α-HSD2Prostaglandin F synthasePGFSChlordecone reductaseDDH1DDXHA1753HAKRBHAKRehluPGFS
02
Mechanism of action
Inhibition of AKR1C3 activity to reduce steroidogenesis or overcome resistance mechanisms.
03
Biological functions
Steroid metabolismProstaglandin metabolismCell proliferationCell differentiationAndrogen biosynthesisAndrogen receptor coactivator
04
Disease associations
CancerHormone-dependent cancersProstate cancerHepatocellular carcinomaEsophageal cancerChemoresistanceRadioresistance
05
Safety considerations
Potential for off-target effects due to sequence similarity with other AKR1C family members.Hormonal imbalances
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