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17-alpha-hydroxylase
- Molecular classification
- Enzyme, Cytochrome P450 monooxygenase
01
Overview
17-alpha-hydroxylase, encoded by the CYP17A1 gene, is an enzyme crucial for steroid hormone biosynthesis. It catalyzes two key reactions: 17α-hydroxylation of pregnenolone and progesterone, and cleavage of the C17-C20 bond to produce DHEA. Deficiencies lead to congenital adrenal hyperplasia, characterized by impaired glucocorticoid and sex hormone production, resulting in hypertension, hypokalemia, and abnormal sexual development.
- Other names
- Steroid 17α-hydroxylase/17,20-lyaseP450c17
02
Mechanism of action
Inhibition of 17-alpha-hydroxylase activity, leading to reduced glucocorticoid and sex steroid synthesis.
03
Biological functions
Glucocorticoid synthesisSex steroid synthesisHydroxylationC-C bond cleavage
04
Disease associations
Congenital adrenal hyperplasiaDisorders of sexual developmentHypertensionHypokalemia
05
Safety considerations
Mineralocorticoid excessHypertensionHypokalemiaAbnormal sexual development
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