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Target intelligence / Profile preview
17beta-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)
- Target
- 17β-HSD1
- Molecular classification
- Enzyme, Oxidoreductase, Steroid dehydrogenase
01
Overview
Human 17β-hydroxysteroid dehydrogenase type 1 is a cytoplasmic oxidoreductase crucial for converting weak estrogens into their most potent form—estradiol—and also participates secondarily in androgen metabolism. Its tissue-specific expression pattern underlies its importance both physiologically—in reproduction—and pathologically—in conditions like ER-positive breast cancer.
- Other names
- Estradiol synthetase17beta-HSD type 1HSD17B1
02
Mechanism of action
Inhibition of 17β-HSD1 activity, leading to reduced estradiol production
03
Biological functions
Steroid hormone metabolismEstrogen synthesisAndrogen metabolismRegulation of sex steroid potency
04
Disease associations
Breast cancerEndometriosisOther hormone-dependent cancers
05
Safety considerations
Potential for off-target effects on other steroidogenic enzymesHormonal imbalances
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