19S Regulatory Particle AAA+ ATPases (19S RP ATPases)

The AAA+ ATPase subunits (Rpt1-Rpt6 or PSMC1-PSMC6) of the 19S regulatory particle are essential components of the eukaryotic ubiquitin-proteasome system (UPS). They form a heterohexameric ring that uses ATP hydrolysis to unfold target proteins and translocate them into the 20S core particle for degradation. The C-terminal tails of these ATPases are critical for opening the gate of the 20S particle. Dysregulation or mutation can contribute to diseases like cancer, making them potential therapeutic targets.

Other names

Proteasome 26S subunit ATPase familyRpt1-Rpt6PSMC1-PSMC6

ATP hydrolysis-dependent protein unfolding and translocation into the 20S proteasome core particle for degradation.