2-Hydroxyacyl-CoA lyase 2 (HACL2)

2-Hydroxyacyl-CoA lyase 2 (HACL2) is an endoplasmic reticulum-localized enzyme in mammalian cells that catalyzes a key cleavage step in the α-oxidation of 2-hydroxy long-chain and very-long-chain fatty acids, converting 2-hydroxyacyl-CoA into a shortened fatty aldehyde and formyl-CoA, thereby contributing to odd-chain fatty acid production[2][5]. It shares homology with the peroxisomal enzyme HACL1 but differs in substrate specificity and subcellular localization[2][5]. HACL2 is implicated in lipid metabolic pathways critical for brain and myelin lipid composition, with potential roles in neurodevelopment and neurodegenerative diseases[5].

Other names

HACL22-Hydroxyacyl-CoA lyase type 22-OH acyl-CoA lyase 2Hydroxyacyl-CoA lyase 2

Not applicable (no known drugs directly targeting HACL2); the enzyme itself catalyzes the cleavage of 2-hydroxyacyl-CoA into a shortened fatty aldehyde and formyl-CoA.