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2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (OGFOD2)
- Target
- OGFOD2
- Molecular classification
- Enzyme, Oxidoreductase, 2-oxoglutarate-dependent dioxygenase family
01
Overview
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (OGFOD2) is an enzyme of the 2-oxoglutarate-dependent dioxygenase family, characterized by the requirement for iron (Fe(II)) and 2-oxoglutarate as cofactors. The precise biological function of OGFOD2 is currently unknown, but it is predicted to have iron ion binding and dioxygenase activity, potentially functioning as a hydroxylase that modifies other proteins, similar to other family members. OGFOD2 is believed to localize in the cytoplasm and, by analogy to the related OGFOD1 protein, may play a role in the cellular stress response, translation regulation, and possibly apoptosis, though these functions remain to be experimentally confirmed. There are currently no approved drugs, established disease associations, or reported biomarker roles for OGFOD2.
- Other names
- 2-oxoglutarate and iron dependent oxygenase domain containing 2FLJ13491FLJ37501DKFZp686H15154MGC120434MGC120436ogfod2 (for nonhuman orthologs)
02
Biological functions
Iron ion binding2-oxoglutarate-dependent dioxygenase activityL-ascorbic acid bindingPutative prolyl or lysyl hydroxylase activityPossible role in stress response, apoptosis, and translational regulation (inferred from analogy to OGFOD1, not directly demonstrated)
03
Disease associations
Other (family associated with conditions including scurvy, cancer, brittle bone disease; no direct disease association or pathogenic variant established for OGFOD2 as of current knowledge)
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