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Target intelligence / Profile preview
20S Proteasome Subunit Beta Type-5 (PSMB5)
- Target
- PSMB5
- Molecular classification
- Enzyme, Peptidase T1B family, Proteasome subunit, Protease
01
Overview
PSMB5 is a catalytic component of the 20S core proteasome complex. It exhibits chymotrypsin-like activity and is responsible for the ATP/ubiquitin-dependent degradation of most intracellular proteins. It participates in both ubiquitin-dependent and ubiquitin-independent protein degradation pathways and plays a crucial role in cell cycle regulation, apoptosis, DNA repair, and antigen processing.
- Other names
- MB1LMPXPSX large multifunctional protease XMacropain epsilon chainMulticatalytic endopeptidase complex epsilon chainProteasome chain 6Proteasome epsilon chainProteasome subunit MB1Proteasome subunit X
02
Mechanism of action
Inhibition of chymotrypsin-like activity of the proteasome
03
Biological functions
Protein degradationProtein homeostasisCell cycle regulationApoptosisDNA repairAntigen processingSpermatogenesis
04
Disease associations
CancerProtein aggregation diseases
05
Interacting drugs
Bortezomib
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