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23S Ribosomal RNA (Bacterial) (23S rRNA)

Target: 23S rRNA
Molecular classification: Ribosomal RNA

Overview

23S ribosomal RNA (23S rRNA) is a large, essential component of the bacterial ribosome's large subunit (50S). It plays a central role in protein synthesis by forming the peptidyl transferase center (PTC), which catalyzes peptide bond formation during translation. It is also a target for many clinically relevant antibiotics.

Other names: Bacterial 23S rRNA23S ribosomal RNA

Mechanism of action

Inhibition of protein synthesis by binding to the peptidyl transferase center or other functional sites in the 23S rRNA, blocking peptide bond formation or translocation.

Biological functions

Peptide bond formationTranslationProtein biosynthesis

Disease associations

Infection

Safety considerations

Antibiotic resistance development due to mutations in the 23S rRNA gene.

Interacting drugs

Macrolides

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