23S ribosomal RNA of Cutibacterium acnes large ribosomal subunit (23S rRNA)

The **23S ribosomal RNA** is a core, essential RNA molecule comprising the catalytic center (peptidyl transferase center) of the large (50S) subunit of bacterial ribosomes, including in *Cutibacterium acnes*. It is responsible for catalyzing peptide bond formation during protein synthesis and is fundamental to ribosomal structure and function[1][6][8]. Domain V forms the peptidyl transferase center, which is targeted by many antibiotics including macrolides, lincosamides, and others[1][8]. Mutations in specific regions of the 23S rRNA (notably domain V) confer resistance to several key antibiotics, making this molecule a validated and clinically important therapeutic target[1][4]. 23S rRNA also participates in ribosome assembly, tRNA positioning, and maintaining the fidelity of translation[2][5]. Detection of resistance-associated sequence changes in 23S rRNA is used as a biomarker for antibiotic resistance in clinical isolates of *C. acnes* and other bacteria.

Other names

23S rRNA23S ribosomal RNALarge ribosomal subunit 23S rRNA

Inhibition of peptide bond formation by binding to the peptidyl transferase center (PTC) Blockage of tRNA binding or movement (A and P loops) Disruption of ribosomal assembly