23S ribosomal RNA peptidyl transferase center (PTC)

The 23S ribosomal RNA peptidyl transferase center (PTC) is the catalytic core of the bacterial 50S ribosomal subunit, functioning as a ribozyme to facilitate protein synthesis [1, 4, 5]. It is responsible for two primary chemical reactions: the formation of peptide bonds between amino acids during translation elongation and the hydrolysis of the peptidyl-tRNA bond during translation termination [4, 5, 13]. The PTC is highly conserved across bacterial species, making it an ideal target for a wide range of antimicrobial agents [1, 14]. Antibiotics such as macrolides, oxazolidinones, lincosamides, and pleuromutilins bind to specific sites within the PTC or the adjacent nascent peptide exit tunnel to inhibit translation, effectively halting bacterial growth [1, 3, 9}

Other names

Peptidyl transferase centerPeptidyltransferase center23S rRNA peptidyl transferaseRibosomal peptidyl transferase50S peptidyl transferase center

Inhibition of protein synthesis by binding to the peptidyl transferase center and blocking peptide bond formation or the exit of the nascent polypeptide chain [1, 3, 9].