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Target intelligence / Profile preview
26S Proteasome β5-Subunit (β5-subunit)
- Target
- β5-subunit
- Molecular classification
- Enzyme, Protease, Peptidase subunit
01
Overview
The β5-subunit is a key component of the 26S proteasome, specifically the 20S core particle. It possesses chymotrypsin-like peptidase activity, crucial for the degradation of ubiquitinated proteins. Its inhibition is a therapeutic strategy in cancer treatment. Proper function is essential for cellular homeostasis and stress response.
02
Mechanism of action
Inhibition of chymotrypsin-like peptidase activity of the 26S proteasome, leading to accumulation of ubiquitinated proteins and induction of apoptosis in cancer cells.
03
Biological functions
Protein degradationProtein homeostasisCell cycle regulationSignal transductionStress responseUbiquitinated protein breakdownChymotrypsin-like peptidase activity
04
Disease associations
CancerAccumulation disordersImmune response dysfunction
05
Interacting drugs
Bortezomib
1 more in the full profile.
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