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Target intelligence / Profile preview
26S Proteasome Beta5-Subunit (PSMB5)
- Target
- PSMB5
- Molecular classification
- Enzyme, Peptidase T1B family, Proteasome subunit
01
Overview
The 26S proteasome beta5-subunit (PSMB5) is a catalytic component of the 20S core particle within the 26S proteasome. It possesses chymotrypsin-like peptidase activity and is crucial for ATP-dependent degradation of ubiquitinated proteins, regulating protein homeostasis by removing misfolded, damaged, or unnecessary proteins. PSMB5 is a clinically validated target in cancer therapy.
- Other names
- Proteasome Subunit Beta Type-5Proteasome chain MB1Macropain epsilon chainMulticatalytic endopeptidase complex epsilon chainProteasome epsilon chainProteasome subunit XLMPXMB1X
02
Mechanism of action
Inhibition of chymotrypsin-like activity of the proteasome
03
Biological functions
Protein degradationProtein quality controlCell cycle regulationStress responseAntigen processingRegulation of transcriptionSignal transductionDNA replication/repair
04
Disease associations
Cancer
05
Interacting drugs
Bortezomib
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