26S proteasome non-ATPase regulatory subunit 9 (PSMD9)

26S proteasome non-ATPase regulatory subunit 9 (PSMD9) is a non-ATPase component of the 19S regulatory particle of the 26S proteasome, a large multi-subunit enzyme complex essential for ATP/ubiquitin-dependent degradation of intracellular proteins. PSMD9 functions as an assembly chaperone for the 19S base subcomplex and is released during later stages of assembly. Emerging evidence indicates roles for PSMD9 in protein quality control, transcriptional regulation via interactions mediated by its PDZ-like domain, mRNA processing, response to cellular stress, protein translation, and potentially linking the proteasome with the unfolded protein response and protein synthesis networks. Dysfunction or altered expression of PSMD9 has been implicated in several human diseases, including certain cancers, neurodegenerative, and metabolic disorders.

Other names

26S proteasome regulatory subunit p27p27Rpn4Bridge 1proteasome 26S subunit non-ATPase 9proteasome (prosome, macropain) 26S subunit non-ATPase 9PSMD9

For general proteasome inhibitors: Inhibition of proteasome-mediated protein degradation, leading to accumulation of ubiquitinated proteins, cell cycle arrest, and apoptosis, particularly in rapidly dividing cells such as in certain cancers