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26S Proteasome Subunit Beta Type-5 (PSMB5)
- Target
- PSMB5
- Molecular classification
- Enzyme, Peptidase T1B family, Proteasome subunit
01
Overview
The 26S proteasome subunit beta type-5 (PSMB5) is a crucial component of the 20S core particle of the proteasome, exhibiting chymotrypsin-like activity. It participates in ATP-dependent degradation of ubiquitinated proteins, maintaining protein homeostasis. It is also involved in ubiquitin-independent degradation, particularly in processes like antigen processing. Dysfunctional PSMB5 can contribute to various diseases, making it a therapeutic target, especially in oncology. Proteasome inhibitors that target PSMB5 are clinically used.
- Other names
- LMPXMB1X chainMacropain epsilon chainMulticatalytic endopeptidase complex epsilon chainProteasome chain 6Proteasome epsilon chainProteasome subunit MB1/X/beta–type–5/beta–subunit–X/beta–subunit MBX
02
Mechanism of action
Inhibition of chymotrypsin-like activity within the proteasome
03
Biological functions
Protein quality controlCell cycle regulationCell growth and differentiationGene transcription regulationSignal transduction pathwaysApoptosisProtein degradation
04
Disease associations
Neurodegenerative diseaseCardiovascular diseaseInflammatory conditionAutoimmune diseaseCancer
05
Interacting drugs
Protease inhibitors (e.g., for multiple myeloma treatment)
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