28S ribosomal RNA

28S ribosomal RNA (rRNA) is a structural component of the large subunit (LSU) of eukaryotic cytoplasmic ribosomes. It plays a critical role in protein synthesis as part of the ribosome, acting as a scaffold for ribosomal proteins and participating directly in catalyzing peptide bond formation. The eukaryotic nuclear 28S rRNA (with its adjacent 5.8S rRNA on the 5' side) serves as the functional homologue to prokaryotic (bacterial/archaeal) 23S rRNA and mitochondrial 16S rRNAs. Targeting processes involving biogenesis or function of this molecule has been explored for anti-cancer therapies due to cancer cells’ dependence on increased protein synthesis capacity via enhanced ribosome production.

Other names

25S–28S rRNA28S rRNA

Targeting ribosome biogenesis or function to inhibit protein synthesis.