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Target intelligence / Profile preview
3β-Hydroxysteroid dehydrogenase type I (3β-HSD1)
- Target
- 3β-HSD1
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
3β-Hydroxysteroid dehydrogenase type I (3β-HSD1) is a key enzyme in the biosynthesis of all classes of active steroid hormones. It catalyzes the oxidation and isomerization of Δ5-3β-hydroxysteroids to Δ4-3-ketosteroids, which are essential steps in producing progesterone, glucocorticoids, mineralocorticoids, androgens, and estrogens. HSD3B1 is predominantly expressed in placenta and peripheral tissues such as breast tissue and is also found in some tumors including breast cancer. Deficiency or mutations in HSD3B1 can lead to disorders such as congenital adrenal hyperplasia. Overexpression or altered activity has been implicated in hormone-dependent cancers like breast cancer.
- Other names
- HSD3B13β-hydroxysteroid dehydrogenase/Δ5-4 isomerase
02
Mechanism of action
Inhibition of 3β-hydroxysteroid dehydrogenase and Δ5-Δ4 isomerase activity
03
Biological functions
Steroid hormone biosynthesisProgesterone synthesisGlucocorticoid synthesisMineralocorticoid synthesisAndrogen synthesisEstrogen synthesis
04
Disease associations
Congenital adrenal hyperplasiaBreast cancerHormone-dependent cancer
05
Safety considerations
Potential for disrupting steroid hormone balanceAdverse effects related to altered hormone levels
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