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Target intelligence / Profile preview
3β-Hydroxysteroid Dehydrogenase Type II (HSD3B2)
- Target
- HSD3B2
- Molecular classification
- Enzyme, Steroid dehydrogenase, Oxidoreductase
01
Overview
3β-hydroxysteroid dehydrogenase type II (HSD3B2) is a crucial enzyme in human steroid hormone biosynthesis. It catalyzes the conversion of Δ5-3β-hydroxysteroids to Δ4-3-ketosteroids, an essential step for producing all classes of active steroid hormones, including glucocorticoids, mineralocorticoids, androgens, estrogens, and progestins. Mutations in HSD3B2 cause congenital adrenal hyperplasia due to impaired synthesis of cortisol, aldosterone, and sex steroids.
02
Mechanism of action
Inhibition of 3β-hydroxysteroid dehydrogenase activity
03
Biological functions
Steroid hormone biosynthesisAndrogen synthesisEstrogen synthesisGlucocorticoid synthesisMineralocorticoid synthesisProgestin synthesis
04
Disease associations
Congenital adrenal hyperplasiaSteroid hormone deficiencySalt-wasting crisisAmbiguous genitaliaUndervirilization
05
Safety considerations
Potential for off-target effects on other steroidogenic enzymesRisk of adrenal insufficiency if enzyme activity is completely blocked
06
Biomarkers
Ratio of Δ5-steroids to Δ4-steroids (e.g., DHEA)HSD3B2 gene mutations
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