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Target intelligence / Profile preview
3β-hydroxysterol Δ24-reductase (DHCR24)
- Target
- DHCR24
- Molecular classification
- Enzyme
01
Overview
DHCR24, or 3β-hydroxysterol Δ24-reductase, is a key enzyme in the cholesterol biosynthesis pathway, catalyzing the reduction of desmosterol to cholesterol. It plays essential roles in tissue development, cholesterol homeostasis, and innate immunity modulation, and is implicated in diseases such as cancer and viral infections.
- Other names
- 3β-hydroxysteroid-Δ24 reductaseDesmosterol reductase
02
Mechanism of action
Inhibition of DHCR24 enzymatic activity
03
Biological functions
Cholesterol biosynthesisLipid metabolism regulationAnti-apoptoticAnti-inflammatoryInnate immunity modulation
04
Disease associations
CancerViral infectionsInflammation
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