Target intelligence / Profile preview

3-chymotrypsin-like Protease (3CLpro)

Target: 3CLpro
Molecular classification: Enzyme, Cysteine protease

Overview

3-chymotrypsin-like protease (3CLpro), also known as main protease or Mpro, is a cysteine protease essential for the life cycle of coronaviruses, including SARS-CoV and SARS-CoV-2. It processes viral polyproteins pp1a and pp1ab, releasing functional nonstructural proteins required for virus replication. 3CLpro cleaves at conserved sites with a preference for glutamine at P1 and small amino acids at P1'. Dimerization is crucial for enzymatic activity. Its essential role and lack of close human homologs make it a validated antiviral drug target.

Other names: Main proteaseMpro

Mechanism of action

Inhibition of viral polyprotein processing

Biological functions

Proteolytic processingViral replication

Disease associations

Infection

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