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Target intelligence / Profile preview
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS)
- Target
- DAH7PS
- Molecular classification
- Enzyme
01
Overview
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase (DAH7PS) is a key enzyme that catalyzes the first step in the shikimate pathway, which is essential for the biosynthesis of aromatic amino acids in bacteria, fungi, and plants but absent in animals. In *Helicobacter pylori*, DAH7PS is an essential protein and a promising novel drug target for the development of antibacterial therapies, particularly in the context of rising antibiotic resistance. Virtual screening and molecular dynamics studies have identified potential small molecule inhibitors, such as 6,8-dihydroxyisocoumarin-3-carboxylic acid and epicatechin, that bind stably to the enzyme and may serve as leads for future antimicrobial drug development. Further experimental validation is needed to confirm therapeutic efficacy and safety[1][2][3].
- Other names
- DAHP synthaseDAHPS3-deoxy-D-arabino-heptulosonate-7-phosphate synthaseDAH7P synthase
02
Mechanism of action
Enzyme inhibition (direct inhibition of DAH7PS enzyme activity)
03
Biological functions
Biosynthesis of aromatic amino acidsShikimate pathwayMetabolic regulation
04
Disease associations
Infection (notably *Helicobacter pylori* infection)Other (potential antimicrobial target)
05
Safety considerations
Potential off-target effects depending on selectivity, but generally low risk as the enzyme is absent in humansmain safety concern would arise if analogous host or microbiome enzymes were inadvertently inhibited
06
Interacting drugs
6,8-Dihydroxyisocoumarin-3-carboxylic acid
1 more in the full profile.
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