3-hydroxy-3-methylglutaryl-CoA reductase pseudogene

The 3-hydroxy-3-methylglutaryl-CoA reductase pseudogene (ENSG00000275012) is a genetically inactive copy of the functional HMG-CoA reductase gene, lacking protein-coding capability due to mutations, frameshift errors, or missing regulatory elements. HMG-CoA reductase, the active enzyme, is a key regulator of cholesterol and isoprenoid biosynthesis targeted by statins, but pseudogenes such as ENSG00000275012 do not encode functional protein and are not implicated in therapeutic interventions or biological roles[3][4]. Their presence may reflect evolutionary history or genetic redundancy; however, they are not considered drug targets, have no known pathophysiological function, and are not associated with disease or clinical applications. *This distinguishes the pseudogene from functional HMG-CoA reductase, an established drug target responsible for cholesterol biosynthesis and the target of statin drugs[3][4].*

Other names

HMGCR pseudogene3-hydroxy-3-methylglutaryl-CoA reductase (pseudogene)Putative HMG-CoA reductase pseudogene