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Target intelligence / Profile preview
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)
- Target
- HMGCR
- Molecular classification
- Enzyme, Reductase
01
Overview
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is the rate-limiting enzyme in the mevalonate pathway, responsible for cholesterol biosynthesis. It is a key therapeutic target for statin drugs, which lower cholesterol levels and reduce cardiovascular risk.
02
Mechanism of action
Competitive inhibition of HMGCR, blocking the conversion of HMG-CoA to mevalonic acid, thereby reducing cholesterol synthesis.
03
Biological functions
Cholesterol biosynthesisLipid metabolismRegulation of mevalonate pathway
04
Disease associations
Cardiovascular diseaseHypercholesterolemia
05
Safety considerations
MyopathyRhabdomyolysisLiver dysfunctionDrug interactions
06
Interacting drugs
Statins (e.g., Atorvastatin, Simvastatin, Rosuvastatin)
07
Biomarkers
LDL-cholesterol levelsTotal cholesterol levelsHMGCR expression levels
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