Target intelligence / Profile preview

3-hydroxyanthranilate oxidase

Molecular classification: Enzyme, Oxidoreductase

Overview

3-hydroxyanthranilate oxidase is an oxidoreductase enzyme (EC 1.10.3.5) that catalyzes the oxidation of 3-hydroxyanthranilate in the presence of oxygen, forming 6-imino-5-oxocyclohexa-1,3-dienecarboxylate and hydrogen peroxide[4]. It is a rare enzyme, minimally studied in higher organisms, and should not be confused with 3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6), which is a well-characterized member of the kynurenine pathway with significant biological and therapeutic relevance. The oxidase has little evidence for involvement in human disease, biomarker applications, or as a drug target[4][5].

Other names: 3-hydroxyanthranilic acid oxidase3-hydroxyanthranilic oxidase3-hydroxyanthranilate:oxygen oxidoreductaseNot to be confused with: 3-hydroxyanthranilate 3,4-dioxygenase, 3-hydroxyanthranilic acid 3,4-dioxygenase (often abbreviated as HAAO or 3-HAO in literature)

Mechanism of action

Not established for drugs (no drugs known) Catalyzes: 3-hydroxyanthranilate + O2 → 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2

Biological functions

Tryptophan metabolism (rare step; most organisms use the 3,4-dioxygenase, not the oxidase, at this position)Other

Disease associations

Other (no established link to major human or animal diseases; most disease relevance in the kynurenine pathway is attributed to 3-hydroxyanthranilate 3,4-dioxygenase rather than the oxidase)

Beyond the preview

Go deeper on 3-hydroxyanthranilate oxidase.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on 3-hydroxyanthranilate oxidase.

Explore the full profile