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Target intelligence / Profile preview
3-phosphoinositide-dependent protein kinase 1 (PDK1)
- Target
- PDK1
- Molecular classification
- Serine/threonine kinase, AGC kinase family, Enzyme
01
Overview
3-phosphoinositide-dependent protein kinase 1 (PDK1 or PDPK1) is a serine/threonine kinase that acts as a central regulator in multiple signaling pathways, particularly those downstream of phosphatidylinositol 3-kinase (PI3K). It is a master kinase for members of the AGC family of kinases, phosphorylating and activating them at their activation loop, which is essential for their full activation. Through its targets, PDK1 regulates critical cellular processes such as cell survival, growth, proliferation, metabolism, differentiation, and translation. It is involved in cancer and other diseases.
- Other names
- PDPK1
02
Mechanism of action
Phosphorylation and activation of AGC family kinases at their activation loop (T-loop).
03
Biological functions
Signal transductionCell survivalCell growthCell proliferationMetabolism regulationDifferentiationTranslation
04
Disease associations
CancerGallbladder cancerEndometrial cancerGlioblastoma
05
Safety considerations
Tumor promotionTherapy resistanceTumor recurrence
06
Biomarkers
Lung non-small cell carcinoma
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