39S ribosomal protein L32, mitochondrial (MRPL32)

39S ribosomal protein L32, mitochondrial (MRPL32) is a nuclear-encoded protein that integrates into the mitochondrial large ribosomal subunit and is essential for mitochondrial protein synthesis[3][5][7][9]. MRPL32 contains a specialized domain that coordinates zinc ions via a conserved cysteine motif (CxxC-X9-CxxC), contributing both to folding and function[2][8]. Its proper processing and maturation are regulated by the m-AAA protease, which ensures that MRPL32 integrates correctly into the ribosome, influencing biogenesis and assembly of mitochondrial respiratory complexes[2][1]. MRPL32 is not an enzyme or a classical therapeutic target such as a receptor, transporter, or ion channel, and there are no drugs currently known to interact directly with it. Defects or dysregulation in MRPL32 may contribute to impaired mitochondrial protein synthesis, with potential secondary relevance in mitochondrial disorders[2][3].

Other names

Large ribosomal subunit protein bL32mHSPC283L32mtMRP-L32bMRP-59bbL32mmitochondrial ribosomal protein L3239S ribosomal protein L32, mitochondrialmitochondrial large ribosomal subunit protein bL32m39S subunit protein L32MRP-L32 protein, S. cerevisiae (ortholog)