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Target intelligence / Profile preview
SARS-CoV-2 Main Protease (Mpro)
- Target
- Mpro
- Molecular classification
- Enzyme, Cysteine protease, Hydrolase
01
Overview
The SARS-CoV-2 main protease (Mpro), also known as 3C-like protease (3CLpro), is a cysteine hydrolase enzyme essential for the life cycle of SARS-CoV-2. It cleaves viral polyproteins pp1a and pp1ab to release nonstructural proteins required for viral replication. Inhibition of Mpro blocks viral replication, making it a prime target for antiviral drug development.
- Other names
- 3C-like protease3CLpro
02
Mechanism of action
Inhibition of Mpro activity, preventing polyprotein processing and viral replication
03
Biological functions
Viral polyprotein processingViral replicationViral transcriptionMaturation of viral proteins
04
Disease associations
InfectionCOVID-19
05
Safety considerations
Potential for drug resistanceOff-target effects (though less likely due to unique specificity)
06
Interacting drugs
Nirmatrelvir
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