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3C-like Proteinase (3CLpro)

Target: 3CLpro
Molecular classification: Enzyme, Cysteine protease

Overview

The 3C-like proteinase (3CLpro), also known as main protease (Mpro) or nonstructural protein 5 (nsp5), is a cysteine protease essential for the life cycle of coronaviruses. It cleaves viral polyproteins at multiple conserved sites, generating functional proteins required for viral replication. Its crucial role and absence from host cells make it an attractive target for antiviral drug development. Inhibitors can halt virus replication, but safety concerns include off-target effects and potential resistance development.

Other names: Main protease (Mpro)Nonstructural protein 5 (nsp5)

Mechanism of action

Inhibition of viral polyprotein processing, leading to disruption of viral replication.

Biological functions

ProteolysisViral polyprotein processingVirus replication

Disease associations

Infection

Safety considerations

Potential for off-target effects due to protease inhibition.Development of resistance through mutations in the protease.

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