40S ribosomal protein S11 (RPS11)

40S ribosomal protein S11 (RPS11) is a structural protein that forms part of the small (40S) ribosomal subunit, essential for ribosome function and effective mRNA translation during protein synthesis[1][2][3][4]. It belongs to the S17P family of ribosomal proteins and participates in both ribosome assembly and the initial steps of pre-rRNA processing. RPS11 is encoded by the RPS11 gene, located on chromosome 19, and is co-transcribed with the small nucleolar RNA gene U35B. RPS11 has been implicated in disease contexts, notably serving as a prognostic biomarker in glioblastoma, reflecting its importance in cellular viability and resilience in cancer stem cells[1][2]. Disruption of its function can lead to hematologic disorders such as Diamond-Blackfan anemia. RPS11 is not a typical therapeutic target and lacking direct drug interactions but remains of interest due to its role in ribosome integrity and disease biology.

Other names

Ribosomal protein S11S11uS17Small ribosomal subunit protein uS1740S ribosomal protein S11RPS11

Not applicable; no drugs directly target RPS11. Some chemotherapeutics may indirectly affect ribosomal proteins or their expression, but these mechanisms are systemic and not specific to RPS11