40S ribosomal protein S17 (RPS17)

40S ribosomal protein S17 (RPS17) is a highly conserved structural protein that is an essential component of the small 40S subunit of the eukaryotic ribosome, which catalyzes protein synthesis in all cells. The RPS17 protein is involved in the assembly and stability of the ribosome as well as in the ribosome's primary function: translating messenger RNA into protein. RPS17 is cytoplasmic, contains nuclear and nucleolar localization signals, and concentrates in the nucleolus during ribosome assembly. Mutations or deletions in RPS17 cause Diamond-Blackfan anemia, a rare congenital disorder characterized by erythroid failure and various congenital anomalies, highlighting the protein’s critical role in hematopoiesis[1][2][3][4][5]. RPS17 is not a typical drug target (such as a receptor, enzyme, or transporter), and no approved drugs are known to specifically interact with or modulate this protein.

Other names

Small ribosomal subunit protein eS17RPS17LRPS17L1RPS17L2MGC72007S17eS17DBA4