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Target intelligence / Profile preview
40S ribosomal protein S20 (RPS20)
- Target
- RPS20
- Molecular classification
- Ribosomal protein, Structural constituent of ribosome, Other
01
Overview
40S ribosomal protein S20 (RPS20) is a component of the small (40S) subunit of the cytoplasmic ribosome, the cellular machinery responsible for protein synthesis. It belongs to the S10P family of ribosomal proteins and is essential for ribosome structure and function. RPS20 gene mutations have been linked to certain diseases, including Diamond-Blackfan anemia and increased risk for familial colorectal cancer[1][2][7][8]. No drugs are currently known to directly target RPS20, and it is not considered a conventional therapeutic target such as a receptor, enzyme, or transporter.
- Other names
- Small ribosomal subunit protein uS10S20uS10small ribosomal subunit protein uS10
02
Biological functions
Protein synthesisStructural constituent of ribosomeCell proliferation
03
Disease associations
CancerDiamond-Blackfan anemiaFamilial colorectal cancerOther
04
Safety considerations
Mutations associated with predisposition to cancers such as familial colorectal cancer and with Diamond-Blackfan anemia[2][7]
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