40S ribosomal protein S23 (RPS23)

40S ribosomal protein S23 (RPS23) is a structural protein component of the small (40S) subunit of cytoplasmic ribosomes, which are responsible for catalyzing protein synthesis in eukaryotic cells[1][3][10]. RPS23 belongs to the S12P family of ribosomal proteins and plays a critical role in ensuring translational accuracy and the proper assembly of the small ribosomal subunit (SSU), participating in RNA binding and ribosome structure formation[1][10]. It is evolutionarily conserved, showing significant similarity with the yeast ribosomal protein S28. Mutations in RPS23 have been linked to rare developmental disorders such as brachycephaly, trichomegaly, and developmental delay, as well as associations with autism spectrum disorder, but RPS23 itself is not generally considered a direct therapeutic target or biomarker in drug discovery[1][5][9][10].

Other names

Small ribosomal subunit protein uS12S23uS12BTDDMABASMCINSPAMAS40S ribosomal protein S23ribosomal protein S23homolog of yeast ribosomal protein S28