40S ribosomal protein S27 (RPS27)

40S ribosomal protein S27 (RPS27) is a zinc finger-containing component of the small 40S ribosomal subunit, encoded by the RPS27 gene[1][2][4]. Its canonical role is as a structural constituent of the ribosome, essential for protein synthesis. The protein binds zinc and nucleic acids, and is found predominantly in the cytoplasm as part of ribosomes, but can also be detected in the nucleus[2][4]. RPS27 is multifunctional, participating in the regulation of cell cycle, response to cellular stress, apoptosis, and DNA repair. Beyond its role in translation, it interacts with the p53–MDM2 axis and influences inflammatory and immune response gene regulation, implicating it in genomic integrity and cellular growth control[1][5]. Pathogenic mutations and abnormal expression of RPS27 have been identified in melanoma, Diamond-Blackfan anemia, and other cancers; heterogenous expression levels serve as biomarkers for these diseases[1][2][4]. Experimental drugs target its zinc finger motif for cancer therapy[2], but ubiquitous ribosomal expression presents major safety challenges. RPS27's regulation and interaction networks, especially its roles in oncogenesis and ribosomal stress, highlight both its therapeutic potential and essential cellular functions.

Other names

Metallopan-stimulin 1metallopanstimulin 1MPS-1S27eS27DBA17Small ribosomal subunit protein eS27

Chelation and inactivation of zinc finger motif in RPS27; in experimental cancer therapy to suppress function Modulation of autophagy by influencing mTORC1 signaling (via RPS27L studies)