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Target intelligence / Profile preview
40S ribosomal protein S28 (RPS28)
- Target
- RPS28
- Molecular classification
- Other (ribosomal protein/small ribosomal subunit component)
01
Overview
40S ribosomal protein S28 (RPS28) is a cytoplasmic protein component of the small (40S) ribosomal subunit and belongs to the S28E family of ribosomal proteins. As part of the ribosome, RPS28 is essential for protein synthesis and ribosome biogenesis, contributing to the assembly and structural integrity of the small subunit. It also plays a regulatory role in the processing of pre-rRNA and modulates peptide generation for MHC class I immunosurveillance by influencing the translation initiation from non-canonical start codons. Mutations in RPS28 can result in bone marrow failure syndromes, particularly Diamond-Blackfan anemia with craniofacial abnormalities, and broader ribosomopathies, highlighting its importance in hematopoiesis and development. No direct drugs target RPS28, and it is not considered a typical therapeutic target, but its dysfunction has diagnostic and clinical relevance in specific anemias and developmental disorders.
- Other names
- Ribosomal protein S28eS28S28DBA15Small ribosomal subunit protein eS28RS28_HUMANRibosomal protein S28e40S ribosomal protein S28
02
Biological functions
Structural constituent of ribosomeProtein synthesisRibosome biogenesisRNA bindingPre-rRNA processingRegulation of peptide generation for immunosurveillance (MHC class I presentation)
03
Disease associations
Bone marrow failure syndromes (e.g., Diamond-Blackfan anemia)Developmental disorders (e.g., craniofacial dysostosis)Other ribosomopathies
04
Safety considerations
Essential for normal cell function; knockdown impairs cell growth, development, and erythropoiesisDysfunction may contribute to ribosomopathies and abnormal immune peptide processing
05
Biomarkers
Mutations serve as biomarkers for Diamond-Blackfan anemia 15 with mandibulofacial dysostosis
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