40S ribosomal protein S29 (RPS29)

40S ribosomal protein S29 (RPS29) is a structural component of the 40S small ribosomal subunit, encoded by the RPS29 gene on chromosome 14[1][2][4]. It contains a C2–C2 zinc finger-like domain important for zinc binding and the integrity of the ribosome[2][3][6]. This protein is required for proper ribosomal assembly and efficient protein synthesis within the cytoplasm[2][3][5]. RPS29 can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1)[2][3][5]. Mutations in RPS29 are causative for Diamond-Blackfan anemia subtype 13, a rare congenital erythroid aplasia; altered expression has been observed in some cancers, though its expression level does not correlate with disease severity[1][2][3]. RPS29 is not known to be a direct therapeutic target or to interact with drugs, and no known biomarkers or direct safety concerns have been recorded.

Other names

Small ribosomal subunit protein uS14S29uS14DBA13ribosomal protein S29