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Target intelligence / Profile preview
5’-Deiodinase Enzyme
- Molecular classification
- Enzyme, Selenoprotein
01
Overview
The 5’-deiodinase enzymes (D1, D2, and D3) are a family of selenoproteins that regulate thyroid hormone activity by catalyzing the removal of iodine atoms from thyroid hormones. D1 and D2 activate T4 to T3, while D3 inactivates T4 and T3. This regulation is crucial for maintaining tissue-specific levels of active thyroid hormone and for developmental control. Alterations in these enzymes can disrupt thyroid hormone homeostasis, leading to disorders such as hypothyroidism/hyperthyroidism or abnormal neurodevelopment.
- Other names
- Iodothyronine 5'-deiodinaseType I deiodinase (D1)Type II deiodinase (D2)Type III deiodinase (D3)Thyroxine 5-deiodinase
02
Mechanism of action
Inhibition of deiodinase activity, reducing T3 production or increasing T4/T3 levels depending on the isoform and context.
03
Biological functions
Thyroid hormone regulationActivation of thyroxine (T4) to triiodothyronine (T3)Inactivation of T4 and T3Regulation of tissue-specific thyroid hormone levelsDevelopmental control during embryogenesis
04
Disease associations
HypothyroidismHyperthyroidismAbnormal neurodevelopment
05
Safety considerations
Disruption of thyroid hormone homeostasisPotential for developmental abnormalities if dysregulated during pregnancy
06
Interacting drugs
Iopanoic acid
1 more in the full profile.
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