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5-alpha reductase type 2 (5α-reductase type 2)
- Target
- 5α-reductase type 2
- Molecular classification
- Enzyme
01
Overview
5α-reductase type 2 is an enzyme that catalyzes the conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen essential for male sexual differentiation. It is encoded by the *SRD5A2* gene. Deficiency or mutations in *SRD5A2* cause disorders of sex development (DSDs) such as ambiguous genitalia or undervirilization in individuals with XY chromosomes. In prostate cancer, the expression of type 2 isoform decreases while type 1 increases. Antiandrogen therapies can block this regulatory mechanism.
- Other names
- SRD5A25-alpha-reductase 2Testosterone 5-alpha-reductase type 2
02
Mechanism of action
Inhibition of 5-alpha reductase type 2, preventing the conversion of testosterone to dihydrotestosterone (DHT)
03
Biological functions
Steroid metabolismAndrogen biosynthesisConversion of testosterone to dihydrotestosterone (DHT)
04
Disease associations
Disorders of sex development (DSDs)5-alpha reductase deficiencyAmbiguous genitaliaUndervirilizationProstate cancer
05
Safety considerations
Sexual dysfunctionGynecomastiaTeratogenicity (potential harm to developing fetus)
06
Interacting drugs
Finasteride
1 more in the full profile.
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