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5-alpha Reductase Type II (5α-Reductase Type II)
- Target
- 5α-Reductase Type II
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
5-alpha reductase type II is an enzyme that catalyzes the irreversible conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen, using NADPH as a cofactor. This reaction is crucial for male sexual differentiation and development, particularly in the formation of external genitalia before birth. It is encoded by the SRD5A2 gene.
- Other names
- Steroid Δ4–5α-reductaseTestosterone 5α-reductaseΔ4–3-Keto steroid 5α-reductase3-oxo-5α-steroid:acceptor Δ4-oxidoreductase
02
Mechanism of action
Inhibition of 5-alpha reductase type II, reducing DHT production.
03
Biological functions
Steroid metabolismAndrogen synthesisSexual differentiationHormone conversion
04
Disease associations
Benign Prostatic Hyperplasia (BPH)Androgenetic Alopecia5-alpha reductase deficiencyDisorders of sexual developmentProstate cancer
05
Interacting drugs
Finasteride
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