Target intelligence / Profile preview

5-Aminosalicylic Acid (5-ASA)

Target: 5-ASA
Molecular classification: Anti-inflammatory drug, Aminosalicylate

Overview

5-Aminosalicylic acid (5-ASA), also known as mesalamine or mesalazine, is an anti-inflammatory drug primarily used for the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease. Its therapeutic effect relies on targeted delivery to the colon, where it exerts local anti-inflammatory actions.

Other names: MesalamineMesalazine

Mechanism of action

Inhibition of cyclooxygenase and lipoxygenase, leading to reduced prostaglandin production. Inhibition of thromboxane synthetase, platelet activating factor synthetase, and interleukin-1. Activation of PPAR-γ.

Biological functions

Anti-inflammatory activityInhibition of prostaglandin synthesisPPAR-γ activation

Disease associations

Ulcerative colitisCrohn's diseaseUlcerative proctitisInflammatory Bowel Disease (IBD)

Safety considerations

Premature release or absorption in the upper gastrointestinal tract reduces efficacySystemic side effects

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