5-hydroxytryptamine (serotonin) receptor 3

The 5-hydroxytryptamine receptor 3 (5-HT₃ receptor) is a ligand-gated ion channel that mediates fast excitatory neurotransmission in both the central and peripheral nervous systems. Upon activation by serotonin, the channel opens to allow Na⁺, K⁺, and Ca²⁺ ions through, resulting in rapid neuronal depolarization and excitation. It plays roles in emesis, cognition, anxiety, gastrointestinal motility, and neurodevelopment. Antagonists like ondansetron are used clinically to prevent nausea/vomiting.

Other names

5-HT₃ receptorType 3 serotonin receptor

Selective antagonists block the receptor's action within brainstem emetic centers, preventing nausea/vomiting.