5-hydroxytryptamine (serotonin) receptor 3E, ionotropic (HTR3E)

5-hydroxytryptamine (serotonin) receptor 3E (HTR3E) is a protein coding gene that encodes an E subunit of the serotonin 5-HT3 receptor, a ligand-gated cation channel of the Cys-loop receptor family. The 5-HT3 receptor consists of five subunits (A–E); HTR3E encodes one of these accessory subunits, which cannot form a functional receptor alone but can combine with other subunits (principally 5-HT3A) to form heteromeric receptor complexes with distinct properties. HTR3E is predominantly expressed in the gastrointestinal tract, especially in enteric neurons and gut epithelium, contributing to gastrointestinal neurotransmission and regulation of intestinal motility and secretion. In the central nervous system, its role is less well defined, but genetic variation in HTR3E has been linked to certain neuropsychiatric conditions, such as obsessive-compulsive disorder. Therapeutically, 5-HT3 receptors, including those containing the E subunit, are targets for antiemetic drugs (e.g., ondansetron) and are being studied for application in gastrointestinal and neuropsychiatric disorders. Mutations or regulatory variations in HTR3E may influence disease risk, treatment response, or side effect profile in conditions involving serotonin signaling.

Other names

5-hydroxytryptamine receptor 3EHTR3E5-HT3-E5-HT3ESerotonin receptor 3E5-HT3c15-hydroxytryptamine (serotonin) receptor 3, family member E5-hydroxytryptamine receptor 3 subunit E

Antagonism or modulation of 5-HT3 receptor (blockade of ligand-gated cation channel, thereby inhibiting serotonin-induced depolarization)