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Target intelligence / Profile preview
5-Hydroxytryptamine Receptor 1B (None)
- Target
- None
- Molecular classification
- G protein-coupled receptor, Receptor
01
Overview
The 5-hydroxytryptamine receptor 1B (5-HT1B) is a G protein-coupled receptor that binds serotonin and is primarily located in the central nervous system and blood vessels. It acts as an inhibitory autoreceptor on serotonergic neurons and as a heteroreceptor on other neurons, modulating neurotransmitter release. Activation leads to vasoconstriction and inhibition of plasma extravasation. It is a target for triptans in migraine treatment and is implicated in mood disorders and addiction. Genetic variations in the HTR1B gene are associated with major depressive disorder, antidepressant response, and suicidal behavior.
- Other names
- Serotonin receptor 1B5-HT1B receptor
02
Mechanism of action
Agonist at 5‑HT₁B receptors; vasoconstriction and inhibition of neurogenic inflammation (triptans). Indirect modulation of 5-HT1B receptor activity may contribute to antidepressant effects.
03
Biological functions
Signal transductionPresynaptic inhibition of neurotransmitter releaseVascular smooth muscle contractionModulation of neurotransmitter releaseRegulation of moodRegulation of memoryRegulation of aggressionRegulation of stress sensitivityRegulation of anxiety
04
Disease associations
MigraineMajor depressive disorderAddictionObsessive-compulsive disorder
05
Safety considerations
Cardiovascular side effects (vasoconstriction)Potential for drug interactions
06
Interacting drugs
Sumatriptan
2 more in the full profile.
07
Biomarkers
HTR1B gene polymorphisms (e.g., rs6296) as potential predictors of antidepressant response and suicidal behavior
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