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5-Hydroxytryptamine Receptor 3
- Molecular classification
- Cys-loop ligand-gated ion channel, Receptor
01
Overview
The 5-hydroxytryptamine receptor 3 (5-HT₃ receptor) is a member of the serotonin receptor family, unique in being a ligand-gated ion channel rather than a G protein-coupled receptor. It mediates fast excitatory neurotransmission in both the central and peripheral nervous systems by allowing cation influx upon activation by serotonin (5-hydroxytryptamine). It is therapeutically important as a target for antiemetic drugs used especially during chemotherapy/radiotherapy. There is ongoing research into their role in neurodevelopmental disorders and psychiatric conditions due to their regulatory effects on neural circuits.
02
Mechanism of action
Agonist or antagonist binding to the 5-HT₃ receptor, modulating cation influx and neuronal excitability.
03
Biological functions
Excitatory neurotransmissionModulation of neurotransmitter release (dopamine, CCK, GABA)Synaptic plasticity
04
Disease associations
Emesis/vomitingAnxietyNeurodevelopmental disordersDrug abusePsychiatric conditions
05
Interacting drugs
SR57227A
3 more in the full profile.
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