5-hydroxytryptamine receptor 3C (5-HT3C)

5-hydroxytryptamine receptor 3C (5-HT3C) is a protein subunit forming part of the pentameric serotonin-gated ion channels (5-HT3 receptors) in the nervous and enteric systems. While the 5-HT3A subunit is essential for forming functional homomeric channels, 5-HT3C can heteropentamerize only in combination with 5-HT3A, modifying the assembly, signaling, and pharmacological properties of the receptor complex. HTR3C is coexpressed in tissues such as myenteric neurons, impacting functions like gastrointestinal motility and central neurotransmission. Genetic variants in HTR3C can influence patient susceptibility and response to therapeutic 5-HT3 antagonists, especially in chemotherapy-induced nausea/vomiting, irritable bowel syndrome, and selected neuropsychiatric disorders, underscoring its relevance both as a constituent of drug targets and as a potential biomarker.

Other names

HTR3C5-HT3C subunitSerotonin receptor 3C subunit

Competitive antagonists block serotonin binding to the orthosteric site in the 5-HT3 receptor complex, preventing channel opening and subsequent neuronal depolarization. Variants in HTR3C may alter efficacy and safety by modifying receptor pharmacodynamics/pharmacokinetics.