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5-hydroxytryptamine receptor 6 (None)
- Target
- None
- Molecular classification
- GPCR, G protein-coupled receptor, Rhodopsin-like GPCR
01
Overview
The 5-hydroxytryptamine receptor 6 (5-HT6 receptor, gene symbol HTR6) is a member of the G protein-coupled receptor (GPCR) family that binds serotonin (5-hydroxytryptamine, 5-HT), an important neurotransmitter in the central nervous system. It is primarily expressed in the brain and plays key roles in modulating neurotransmission and neuronal signaling. Upon binding serotonin or other agonists, it activates Gs proteins which stimulate adenylate cyclase activity, leading to increased intracellular cAMP levels. This signaling cascade influences various downstream effectors involved in neuronal activity. It has been investigated extensively as a drug target for several neuropsychiatric conditions.
02
Mechanism of action
Coupled via Gs protein → stimulates adenylate cyclase → ↑cAMP
03
Biological functions
Signal transductionModulates neurotransmitter releaseRegulates neuron migrationActivates mTOR
04
Disease associations
Alzheimer's diseaseCognitive impairmentObesityDepressionOCDAnxiety
05
Safety considerations
Clinical trial results have been disappointing regarding efficacy improvement over placebo controls for cognitive disorders like Alzheimer's disease or schizophrenia-related cognitive deficits.Net effect depends on cellular context due to co-localization with inhibitory interneurons like those using GABA as a transmitter.
06
Interacting drugs
Latrepirdine
10 more in the full profile.
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