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5-hydroxytryptamine receptor 7, isoform a (5-HT7A)
- Target
- 5-HT7A
- Molecular classification
- G protein-coupled receptor, Receptor, 7-transmembrane receptor
01
Overview
The **5-hydroxytryptamine receptor 7, isoform a (5-HT7A)** is a G protein-coupled receptor encoded by the HTR7 gene, with several splice variants including 7A. This receptor is widely distributed in the central nervous system and is implicated in the modulation of mood, cognition, circadian rhythm, and neurodevelopment. Antagonism of 5-HT7A, as exerted by vortioxetine and some other drugs, has been associated with antidepressant and pro-cognitive effects[1][3][4][5]. The 5-HT7A isoform specifically participates in cAMP-dependent intracellular signaling and regulates pathways such as PKA, EPAC, and mTOR, with downstream impact on synaptic plasticity and neuronal growth[4].
- Other names
- serotonin receptor 7A5-HT7A receptorHTR7A
02
Mechanism of action
Antagonism of 5-HT7A inhibits cAMP production and downstream signaling, contributing to antidepressant, anxiolytic, and cognitive-enhancing effects
03
Biological functions
Signal transductionRegulation of cAMP levelsModulation of synaptic plasticity and neurodevelopment
04
Disease associations
Neuropsychiatric disorders (including depression, anxiety)Cognitive dysfunctionOther central nervous system disorders
05
Interacting drugs
Vortioxetine
1 more in the full profile.
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