5-hydroxytryptamine receptor 7 isoform a (5-HT7A) (5-HT7A)

The 5-hydroxytryptamine receptor 7 isoform a (5-HT7A) is a specific splice variant of the 5-HT7 receptor, a G protein-coupled receptor (GPCR) that stimulates adenylyl cyclase via the Gs signaling pathway to increase intracellular cAMP [1, 2]. It is the most prevalent isoform in human tissues and is widely expressed in the central nervous system, particularly in the hypothalamus, thalamus, and hippocampus [1, 3]. In these regions, the receptor plays a critical role in regulating circadian rhythms, sleep-wake cycles, and cognitive processes such as learning and memory [2, 4]. Beyond the brain, the 5-HT7 receptor is involved in smooth muscle relaxation within the gastrointestinal tract and vasculature [2, 5]. Clinically, it is a significant target for neuropsychiatric conditions; several atypical antipsychotics and antidepressants, including lurasidone and vortioxetine, act as high-affinity antagonists or modulators at this receptor to treat depression and cognitive impairment [4, 5].

Other names

HTR7Serotonin receptor 75-HT75-hydroxytryptamine receptor 7 isoform a5-HT7R

Modulation of Gs-protein signaling to regulate intracellular cyclic adenosine monophosphate (cAMP) levels, thereby influencing neuronal excitability and smooth muscle tone [1, 2].